Introduction. With report of cases of griseofulvin resistant dermatophytes, the use of new Antifungal drugs such as itraconazole, fluconazole and terbinafine is recommended which are more expensive or somehow rare in Iran. Therefore, study of griseofulvin sensitivity pattern of dermatophytes in Isfahan could lead to a more effective and less expensive treatment for ermatophytoses.
Methods. Fifty isolates of the most prevalent dermatophytes in Isfahan were isolated from patients and then the standard homogenized suspensions from them were prepared for future inoculation. The minimum inhibitory concemtration (MIC) of Griseofulvin was determined by modified macrodiution method for each isolate and then results were compared and analysed with standard values of MICs of dermatophytes and the resistant species indentified.
Results. All tested isolates (related to four species) had MIC mode of 0.25, 90% had 8 and 50% ranged . between